ScaffoldLyo
3D coprinted scaffold for tissue enginering
PCT patent pending application
Functionalized with lyosecretome (a freeze-dried formulation of MSC secretome, containing proteins and extracellular vesicles)
Time-controlled release of lyosecretome by changing scaffold porosity and design
Made with biocompatible thermoplastic and natural hydrogel(s)
Easy to produce in sterilize conditions
ScaffoldLyo is the solution for. . .
…improving in vitro cell differentiation and in vivo colonization when scaffold is implanted
The lyosecretome is laden into the hydrogel(s) to achieve controlled release of lyosecretome up to 10 days
It is possible to control the release kinetics of proteins and EVs by changing the composition of the hydrogel, the scaffold’s shape, and hydrogel crosslinking
The lyosecretome greatly improves osteoinductive and osteocontuctive potency of the scaffold
Prototypes for medical devices are available for bone regenerative medicine applications
Biomedicine (submitted, under review)